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Seth O. Fremin

Graduate Student

2025-

SOF61@pitt.edu

https://scholar.google.com/citations?user=tfxSwo0AAAAJ

A.A. in Chemistry, Lonestar Community College System, (2020-2022)
B.Sc. in Biochemistry, University of Texas at San Antonio, (2022-2025)

Seth uses computational modeling and machine learning to study radical-mediated reactivity in transition-metal and photocatalysis, enabling predictive catalyst design.

Seth O. Fremin
Research Interest

My research integrates computational chemistry with machine learning and artificial intelligence to develop and rationalize new reactions across C–X activation, enantioselective synthesis, and photoredox catalysis. These in silico approaches rapidly elucidate reaction mechanisms and the fundamental origins of reactivity and selectivity, enabling rational interpretation of experimental results and model-guided design of efficient transition-metal catalysts.

Awards

  • University of Pittsburgh Chair’s Scholar Summer Research Fellowship  (2025)

  • National Science Foundation Graduate Research Fellowship (NSF-GRFP) (2025)

  • UTSA Janice and Micheal Doyle Endowed Research Award in Chemistry (2024)

  • UTSA Outstanding Undergraduate in the College of Sciences (2024)

Media Coverage

  • Bioengineer.org — “Crafting Sulfur Stereocenters via Asymmetric Geminate Recasting,” covering Porey et al., Nature Chemistry (2025)

  • News.utsa.edu — “Four from UTSA earn prestigious National Science Foundation fellowship”. (2025)

  • Sciences.utsa.edu — College of Sciences Spotlight, Student Research Highlight. (2024)

Previous Publications

  1. Porey, A.; Trevino, R.; Nand, S.; Fremin, S. O.; Dhakal, S. K.; Dhungana, B. R.; Das, A.; Nguyen, V. T. B.; Thompson, W. T.; Moran, D. P.; et al. Construction of sulfur stereocentres by asymmetric geminate recasting. Nature Chemistry 2025, 17 (12), 1862-1870. DOI: 10.1038/s41557-025-01996-5

  2. Huang, S.; Trevino, R.; Zuo, D.; Tian, X.; Yang, W.; Hughes, W. B.; Fremin, S. O.; Porey, A.; Nguyen, V. T. B.; Gao, B.; et al. Cobalt-Catalyzed Enantioconvergent Decarboxylative N-Alkylation. Journal of the American Chemical Society 2025, 147 (24), 21097-21108. DOI: 10.1021/jacs.5c06317

  3. Clarkson, A. J.; Fremin, S. O.; Johnson, J. S. Crystallization-Induced Diastereomer Transformations of Donor–Acceptor Cyclopropanes. Journal of the American Chemical Society 2025, 147 (43), 39870-39878. DOI: 10.1021/jacs.5c14503

  4. Biswas, S.; Trevino, R.; Fremin, S. O.; Sanchez-Palestino, L. M.; Dhungana, B. R.; Porey, A.; Hughes, W. B.; Arman, H. D.; Larionov, O. V.; Doyle, M. P. Photolytic Access to Oxaspirodecanes and Chromenes from Vinyldiazo Ester Cycloaddition with p-Quinones: A Vinylcarbene Is Not Involved. Journal of the American Chemical Society 2025, 147 (14), 12308-12317. DOI: 10.1021/jacs.5c02500

  5. Sui, X.; Dang, H. T.; Porey, A.; Trevino, R.; Das, A.; Fremin, S. O.; Hughes, W. B.; Thompson, W. T.; Dhakal, S. K.; Arman, H. D.; et al. Acridine photocatalysis enables tricomponent direct decarboxylative amine construction. Chemical Science 2024, 15 (25), 9582-9590. DOI: 10.1039/D4SC02356K

  6. Porey, A.; Fremin, S. O.; Nand, S.; Trevino, R.; Hughes, W. B.; Dhakal, S. K.; Nguyen, V. D.; Greco, S. G.; Arman, H. D.; Larionov, O. V. Multimodal Acridine Photocatalysis Enables Direct Access to Thiols from Carboxylic Acids and Elemental Sulfur. ACS Catalysis 2024, 14, 6973-6980. DOI: 10.1021/acscatal.4c01289

  7. Biswas, S.; Hughes, W. B.; De Angelis, L.; Haug, G. C.; Trevino, R.; Fremin, S. O.; Arman, H. D.; Larionov, O. V.; Doyle, M. P. The “cesium effect” magnified: exceptional chemoselectivity in cesium ion mediated nucleophilic reactions. Chemical Science 2024, 15, 5277-5283. DOI: 10.1039/D4SC00316K

  8. Dang, H. T.; Porey, A.; Nand, S.; Trevino, R.; Manning-Lorino, P.; Hughes, W. B.; Fremin, S. O.; Thompson, W. T.; Dhakal, S. K.; Arman, H. D.; et al. Kinetically-driven reactivity of sulfinylamines enables direct conversion of carboxylic acids to sulfinamides. Chemical Science 2023, 14, 13384-13391. DOI: 10.1039/D3SC04727J

  9. Zhang, J.; Zhuang, K.; Trevino, R.; Dhungana, B. R.; Sun, H.; Yin, S.; Li, Y.; Sanchez, J. A.; Xia, X.; Elerian, R.; et al. Dispersion-Enhanced Nitrogen-Centered Photocatalysis of the Direct Hydrogen Atom Transfer. Angewandte Chemie International Edition in press, e22022. DOI: 10.1002/anie.202522022

  10. Das, A.; Dhakal, S. K.; Trevino, R.; Fremin, S. O.; Nguyen, V. T. B.; Porey, A.; Nand, S.; Giri, C. K.; Wherritt, D. J.; Arman, H. D.; et al. Enantioconvergent Access to Chiral S(VI) Stereocenters by Kinetic Resolution of Sulfonimidoyl Chlorides. Angewandte Chemie International Edition in press, e19733. DOI: 10.1002/ange.202519733

 


Publications in the Liu Group

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